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(A and B) Neighborhood expression score (NES) for every gene was calculated as the median expression values of three upstream and three downstream genes. The NES was used as a measure of LRES. A and B shows distribution of the NES values for genes methylated in both SW480 and RKO (A) and genes methylated only in SW480 or only in RKO (B). S and R in legend denote SW480 and RKO.
