Skip to main content
. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: Mol Cell Neurosci. 2010 Nov 27;46(2):368–380. doi: 10.1016/j.mcn.2010.11.008

Figure 4.

Figure 4

Effect of Epac2 or Epac2 rare non-synonymous variants on dendritic spine remodeling and synaptic function. (A) Activation of Epac2 results in dendritic spine shrinkage, and removal of AMPA GluR2/3 from synapses. These effects are consistent with synapse destabilization. (B) Ectopic expression of Epac2 mutants V646F or T809S result in either an increase in dendritic spine size, accompanied with an increase in PSD-95 content (Epac2-V646F), or an increase in the number of dendritic spines and PSD-95 clusters (Epac2-T809S). These effects on spine density are consistent with previously reported effects of hypo- or hyperactivity of Rap, respectively.