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. Author manuscript; available in PMC: 2011 Dec 22.
Published in final edited form as: J Am Chem Soc. 2010 Nov 24;132(50):17751–17759. doi: 10.1021/ja104496q

Scheme 3.

Scheme 3

Protonic interactions and covalency changes in the transition state for rate-limiting decomposition of the tetrahedral intermediate in the deacylation stage of DmAChE catalysis.