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. 2011 Jan 14;10:8. doi: 10.1186/1475-2875-10-8

Table 1.

In vitro activity of chloroquine, quinine, mefloquine, monodesethylamodiaquine, lumefantrine, pyrimethamine, atovaquone, dihydroartemisinin and doxycycline against 36 strains of Plasmodium falciparum under controlled incubator conditions (10% O2) and Genbag® conditions (15% O2)

Compound O2 % IC50 t-test p-value
Geometric mean 95%CI Min Max
Chloroquine 10 127 nM 77-211 8 1032 <0.0001
15 94 nM 61-146 12 751
Quinine 10 580 nM 451-745 153 1752 <0.0001
15 439 nM 336-573 96 1288
Mefloquine 10 57.5 nM 50.7-65.3 30.8 131.0 0.0011
15 49.7 nM 44.0-46.3 26.4 113.0
Monodesethylamodiaquine 10 41.4 nM 28.8-59.6 4.7 379 <0.0001
15 31.8 nM 21.8646.2 4.0 357
Lumefantrine 10 23.8 nM 19.6628.8 7.1 65.0 0.0044
15 21.2 nM 17.5-25.7 7.2 72
Pyrimethamine 10 273 nM 88-852 10 17025 0.0902
15 222 nM 67-735 10 14938
Atovaquone 10 1.2 nM 0.8-1.8 0.1 7.3 0.0011
15 2.1 nM 1.6-2.8 0.2 11.7
Dihydroartemisinin 10 2.4 nM 2.0-2.9 1.2 10.8 0.4088
15 2.4 nM 1.9-2.9 1.0 14.3
Doxycycline 10 10.9 μM 9.8-12.1 7.6 26.0 0.6771
15 10.8 μM 9.5-12.2 6.3 24.5
cpm 10 2738 2628-2852 671 17845 <0.0001
15 2282 2189-2379 623 12726