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. 2010 Jul 20;148(4):467–479. doi: 10.1093/jb/mvq080

Fig. 1.

Fig. 1

Enzyme inhibition mechanisms. In mechanism 1, the binding of inhibitor and isomerization of the complex are simultaneous and not distinguishable and therefore, k1 and k–1 represent the overall on-rate and off-rate constants. In mechanism 2, on the other hand, inhibition of enzyme occurs in two steps, characterized by the formation of a loose EI complex described by rate constants k1 and k–1 and isomerization of EI–EI* (the stable complex) occurs with an on-rate of k2 and an off-rate of k–2.