Table II.
Ki [nM] | ||||
---|---|---|---|---|
Inhibitors | FXIa | Kallikrein | Plasmin | Trypsin |
PN2KPI | 0.81 | 183 | 459 | 0.03 |
PN2KPI-P13A | 2.96 | 1005 | 2,690 | 0.048 |
PN2KPI-R15A | NIb | NIb | NIb | NIb |
PN2KPI-M17A | 0.81 | 7.4 | 479 | 0.054 |
PN2KPI-S19A | 0.93 | 253 | 615 | 0.024 |
PN2KPI-R20A | 2.83 | 6,320 | 914 | 0.041 |
PN2KPI-F34A | 4.92 | 398 | 2,640 | 0.088 |
aTrypsin data represent fluorogenic assay results, whereas the results for the rest of the enzymes are based on chromogenic assays.
bNo inhibition observed at inhibitor concentrations up to 4 µM.