Table II.

Inhibition of FXIa, plasma kallikrein, plasmin and trypsin by PN2KPI mutants^a.

Ki [nM]
Inhibitors	FXIa	Kallikrein	Plasmin	Trypsin
PN2KPI	0.81	183	459	0.03
PN2KPI-P13A	2.96	1005	2,690	0.048
PN2KPI-R15A	NIb	NIb	NIb	NIb
PN2KPI-M17A	0.81	7.4	479	0.054
PN2KPI-S19A	0.93	253	615	0.024
PN2KPI-R20A	2.83	6,320	914	0.041
PN2KPI-F34A	4.92	398	2,640	0.088

^aTrypsin data represent fluorogenic assay results, whereas the results for the rest of the enzymes are based on chromogenic assays.

^bNo inhibition observed at inhibitor concentrations up to 4 µM.