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. 2011 Jan 25;124(4):523–531. doi: 10.1242/jcs.078790

Fig. 5.

Fig. 5.

Demonstration of abnormal lipid accumulation in the Nuc1 RPE. (A,B) At 10 months of age, minimal autofluorescence is seen in the RPE cells of the wild-type animals (A). However, abundant autofluorescence (arrows) is observed in the RPE of 10-month-old Nuc1 animals, consistent with accumulation of lipofuscin (B). (C,D) Autofluorescence viewed with a red filter (560–620 nm). Oil Red O staining, indicating the presence of neutral lipids, shows abundant intense staining in the RPE cells of the 10-month-old Nuc 1 retinas (D, arrows), but not in the control wild-type animals (C). Scale bars: 50 μm.