Table 3.
Multivariable logistic regression analysis for achievement of CR, DFS, and OS in older CN-AML patients
| Group | CR* |
DFS† |
OS‡ |
||||||
|---|---|---|---|---|---|---|---|---|---|
| OR | 95% CI | P | HR | 95% CI | P | HR | 95% CI | P | |
| BAALC, low vs high | 4.32 | 1.83-10.20 | < .001 | 0.64 | 0.42-0.97 | .03 | 0.49‖ | 0.34-0.71 | <.001 |
| ERG, low vs high | 0.69 | 0.48-0.97 | .03 | ||||||
| NPM1, mutated vs wild-type | 2.34 | 1.03-5.35 | .04 | ||||||
| FLT3-ITD, present vs absent | 1.79§ | 1.11-2.87 | < .001 | ||||||
| WBC, each 50-unit increase | 0.68 | 0.49-0.93 | .02 | ||||||
| Age, each 10-year increase | 0.65 | 0.42-1.00 | .05 | ||||||
Odds ratios greater than (less than) 1.0 mean higher (lower) CR rate for the higher values of the continuous variables and the first category listed for the categorical variables. Hazard ratios greater than (less than) 1.0 indicate higher (lower) risk for relapse or death (DFS) or death (OS) for the higher values of the continuous variables and the first category listed for the categorical variables.
Variables considered in the model based on univariable analyses were BAALC expression (low vs high; median cut), ERG expression (low vs high; median cut), NPM1 (mutated vs wild-type), WBC (in 50-unit increments), and age (in 10-year increments).
Variables considered in the model based on univariable analyses were BAALC expression (low vs high; median cut), ERG expression (low vs high; median cut), FLT3-ITD (positive vs negative), FLT3-TKD (positive vs negative), and age (in 10-year increments).
Variables considered in the model based on univariable analyses were BAALC expression (low vs high; median cut), ERG expression (low vs high; median cut), NPM1 (mutated vs wild-type), FLT3-ITD (positive vs negative), and platelet count.
Does not meet the proportional hazards assumption. Low BAALC was associated with better OS until approximately 2 years, and after that, did not seem to impact OS. The hazard ratio for BAALC, low vs high, is reported at 1 year.
Does not meet the proportional hazards assumption. FLT3-ITD was associated with worse DFS until approximately 1 year, and after that, its adverse impact for DFS declined. The hazard ratio for FLT3-ITD is reported at 9 months.