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Phenotypic analysis of mice expressing a mutated (C294Y) hepatocyte-specific Hfe transgene (HfeC294Y tg). Schematic drawing of the HfeC294Y tg construct (A). (B-C) Box plots depicting the measurement of serum transferrin saturation (%; B), and non-heme liver iron (μg/g wet weight; C). WT (n = 7), Hfe−/− (n = 13) and Hfe−/− HfeC294Y tg (n = 16), are depicted in box plots as in Figure 1.
