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Loss of Hjv prevents expression of the Hfe-transgenic phenotype. Box plots depicting (A) serum transferrin saturation (%), and (B) non-heme liver iron (μg/g wet weight) in WT or Hjv−/− animals expressing either a full-length (HfeWT) or HfeΔCD−MYC tg. WT (n = 5), Hjv−/− (n = 8), Hjv−/− HfeWT transgene (n = 6), Hjv−/− (n = 9), Hjv−/− HfeΔCD−MYC tg (n = 8) are shown. Liver hepcidin (Hamp; C), Id1 (D), and Bmp6 (E) mRNA was analyzed and results were depicted as in Figure 2.
