Table 2.
QTL indentified in single-locus and pairwise scans
| QTL name* | Chr | Cross | Peak (cM) | Peak (Mb)† | 95% CI (Mb)† | LOD | Nearest marker | High allele | Human homologous region(s) surrounding peak§ |
|---|---|---|---|---|---|---|---|---|---|
| Chcmq1 | 2 | NZxSM | 60.2 | 120.0 | 24.03-135.14 | 2.2 | D2MIT100 | SM | 11p13, 2q31.2, 11p14, 15q15 |
| 2 | Bx129SI | 56.7 | 109.6 | 90.44-158.19 | 4.2‡ | rs6318808 | B | 11p12, 11p13, 15q26 | |
| 2 | C3xD | 57.4 | 113.5 | 23.29-134.53 | 2.3 | rs3681744 | C3 | 11p12, 11p13, 15q26 | |
| 2 | KSxSM | 46.2 | 77.5 | 57.52-127.96 | 4.2‡ | D2MIT300 | KS | 2q31-q32, 20q13, 2q21-q23, 11p12-p13 | |
| 2 | MRxSM | 22.3 | 33.0 | 10.95-52.49 | 2.9 | rs13476460 | MR | 9q33-q34 | |
| Chcmq2 | 9 | KSxSM | 58.7 | 107.6 | 73.28-114.49 | 7‡ | D9MIT198 | SM | 3p21, 3q23, 3p22 |
| 9 | AxB | 58.5 | 107.5 | 56.57-114.93 | 3.9‡ | rs3700340 | A | 3p21, 3q23, 3p22 | |
| 9 | Cbyx129SI | 56.4 | 104.0 | 92.59-114.38 | 6.1‡ | rs3706728 | CBy | 3q22, 3p21, 3q23, | |
| 9 | 129SIxA | 54.4 | 102.3 | 96.27-107.52 | 15.5‡ | rs3696932 | A | 3q22-q23, 3p21 | |
| Chcmq3 | 7 | Bx129SI | 54.9 | 110.0 | 103.25-114.37 | 80.8‡ | rs3717027 | 129SI | 11p15, 16p12, 16p13, |
| 7 | BxWSB | 55.7 | 112.1 | 96.64-117.94 | 15.7‡ | D7MIT220 | WSB | 16p13, 16p12, 11p15 | |
| 7 | AxB | 56.8 | 114.5 | 97.82-122.27 | 6.7‡ | rs3681072 | A | 11p15, 16p12, 16p13 | |
| 7 | BxCB | 60 | 121.8 | 101.62-127.28 | 4.6‡ | rs3684285 | CB | 16p11, 16p12, 10q25-q26 | |
| 7 | BxD | 48.8 | 94.4 | 85.93-127.52 | 7.3‡ | rs3654319 | D | 11q14, 11q13, 11q15, 4p16 | |
| 7 | MRxSM | 54.9 | 110.6 | 104.10-124.71 | 20.2‡ | rs3717027 | MR | 16p12, 16p13, 11p15 | |
| 7 | NZxSM | 53.8 | 105.6 | 96.63-117.87 | 18.9‡ | D7MIT30 | NZ | 11p15, 16p13-p12 | |
| Chcmq4 | 11 | NZxSM | 47.8 | 80.2 | 46.17-90.59 | 4‡ | D11MIT30 | SM | 17q21, 17q11, 17q12, 17p13, 17q22-q23, 17p13 |
| Chcmq5 | 6 | Bx129SI | 43.8 | 94.9 | 88.49-125.75 | 3.7‡ | rs30129127 | B | 3p26 |
| 6 | CByxC3 | 28.6 | 59.4 | 42.22-116.98 | 3.9‡ | rs3680652 | CBy | 4q22, 4q21, 7q14, 7p11 | |
| 6 | KSxSM | 53.8 | 116.5 | 63.71-137.88 | 2.3 | D6MIT149 | KS | 22q11, 12p13, 12p11, 10q11, 7q36 | |
| 6 | NZxSM | 59.7 | 125.7 | 94.82-137.84 | 2.3 | D6MIT52 | SM | 12p13, 12p12-p11, 12q13 | |
| 6 | MRxSM | 4.9 | 11.0 | 6.56-136.45 | 2.5 | rs29926568 | MR | 7q21-q22, 7q31-q32 | |
| Chcmq6‖ | 12 | C3xD | 33.7 | 77.7 | 68.04-89.05 | — | rs3700554 | C3/D (M), D (F) | 14q23-q24 |
| Chcmq7‖ | 18 | KSxSM | 40.5 | 68.3 | 49.49-73.54 | — | D18MIT208 | SM (F) | 18q21, 18p11 |
| Chcmq8‖ | 11 | BxD | 70.9 | 107.8 | 94.65-113.41 | — | rs13481179 | D (F) | 17q23-q24, 17q25 |
| Chcmq9‖ | 9 | KSxSM | 38.7 | 69.6 | 56.85-110.67 | — | D9MIT198 | SM (M) | 15q21, 15q21-q23 |
| Chcmq10‖ | 8 | MRxSM | 8.7 | 16.9 | 16.86-131.24 | — | rs13479624 | MR (M), SM (F) | 8p23-p22, 8p12, 8p11, 13q14 |
| Chcmq11‖ | 9 | CBy129SI | 32.4 | 59.3 | — | — | rs3685575 | CBy (M) | 11q23, 15q22, 15q23-q25 |
| Chcmq12‖ | 8 | 129SIxA | 31.9 | 64.9 | 34.25-128.56 | — | rs3678134 | 129S1 (M) | 4q31, 8p23-p21, 4q34, 4q31-q32, 4q33, 19p13-p12 |
| Chcmq13¶ | 8 | 129S1xA | 65.8 | 120.5 | — | — | rs13479965 | — | 16q24, 16q22-qter, 1q42, 10p11 |
| Chcmq14¶ | 14 | 129S1xA | 34.6 | 67.6 | — | — | rs13482140 | — | 8p21, 13q14 |
| 1 | C3xD | 41.8 | 81.7 | 66.58-195.10 | 2.4 | rs3022821 | C3 | 2q35, 2q33-q35, 2q35-q36 | |
| 1 | BxWSB | 75.1 | 169.6 | 12.8-194.3 | 1.5 | D1MIT16 | WSB | 1q31, 1q32, 1q25, | |
| 5 | BxWSB | 60.4 | 120.3 | 111.9-139.6 | 2.4 | D5Mit367 | WSB | 22q12, 12q24, 22q11, 1p22, 12q24 | |
| 9 | BxWSB | 14.4 | 28.4 | 28.4-75.7 | 1.6 | D9MIT64 | 11q24, | 11q24, 11q23 | |
| 17 | BxWSB | 17.9 | 32.9 | 39.2-72.4 | 1.5 | D17MIT175 | WSB | 19p13, 6p21, 21q22 | |
| 15 | CByx129SI | 33.8 | 72.6 | 41.12-84.31 | 2.2 | rs13482655 | CBy | 8q24, 8q23-q24 | |
| 19 | KSxSM | 29.4 | 34.3 | 14.90-37.32 | 2.6 | D1MIT88 | KS | 10q23, 10q25, 10q26 |
LOD scores are not given for sex-specific QTL, which are identified by the difference in LOD scores between sex-additive and sex-interactive scans (see “Methods”). LOD scores and 95% CIs are not given for QTL that interact significantly but by themselves are not significant.
QTL names are given for the cross in which each was first identified. Loci on the same chromosome identified in subsequent crosses may or may not be the same QTL (see text).
Megabase (Mb) positions (Build 37) were determined using the Center for Genome Dynamics (http://cgd.jax.org) Mouse Map Converter Tool.
Significant LOD score.
Homologous positions identified using Mouse Genome Informatics Mouse-Human Orthology Maps (http://www.informatics.jax.org).
QTL identified from pairwise search for gene interactions.
Sex-specific QTL: M, male; F, female.