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. 2010 Sep 10;116(25):e139–e149. doi: 10.1182/blood-2010-05-283879

Table 2.

QTL indentified in single-locus and pairwise scans

QTL name* Chr Cross Peak (cM) Peak (Mb) 95% CI (Mb) LOD Nearest marker High allele Human homologous region(s) surrounding peak§
Chcmq1 2 NZxSM 60.2 120.0 24.03-135.14 2.2 D2MIT100 SM 11p13, 2q31.2, 11p14, 15q15
2 Bx129SI 56.7 109.6 90.44-158.19 4.2 rs6318808 B 11p12, 11p13, 15q26
2 C3xD 57.4 113.5 23.29-134.53 2.3 rs3681744 C3 11p12, 11p13, 15q26
2 KSxSM 46.2 77.5 57.52-127.96 4.2 D2MIT300 KS 2q31-q32, 20q13, 2q21-q23, 11p12-p13
2 MRxSM 22.3 33.0 10.95-52.49 2.9 rs13476460 MR 9q33-q34
Chcmq2 9 KSxSM 58.7 107.6 73.28-114.49 7 D9MIT198 SM 3p21, 3q23, 3p22
9 AxB 58.5 107.5 56.57-114.93 3.9 rs3700340 A 3p21, 3q23, 3p22
9 Cbyx129SI 56.4 104.0 92.59-114.38 6.1 rs3706728 CBy 3q22, 3p21, 3q23,
9 129SIxA 54.4 102.3 96.27-107.52 15.5 rs3696932 A 3q22-q23, 3p21
Chcmq3 7 Bx129SI 54.9 110.0 103.25-114.37 80.8 rs3717027 129SI 11p15, 16p12, 16p13,
7 BxWSB 55.7 112.1 96.64-117.94 15.7 D7MIT220 WSB 16p13, 16p12, 11p15
7 AxB 56.8 114.5 97.82-122.27 6.7 rs3681072 A 11p15, 16p12, 16p13
7 BxCB 60 121.8 101.62-127.28 4.6 rs3684285 CB 16p11, 16p12, 10q25-q26
7 BxD 48.8 94.4 85.93-127.52 7.3 rs3654319 D 11q14, 11q13, 11q15, 4p16
7 MRxSM 54.9 110.6 104.10-124.71 20.2 rs3717027 MR 16p12, 16p13, 11p15
7 NZxSM 53.8 105.6 96.63-117.87 18.9 D7MIT30 NZ 11p15, 16p13-p12
Chcmq4 11 NZxSM 47.8 80.2 46.17-90.59 4 D11MIT30 SM 17q21, 17q11, 17q12, 17p13, 17q22-q23, 17p13
Chcmq5 6 Bx129SI 43.8 94.9 88.49-125.75 3.7 rs30129127 B 3p26
6 CByxC3 28.6 59.4 42.22-116.98 3.9 rs3680652 CBy 4q22, 4q21, 7q14, 7p11
6 KSxSM 53.8 116.5 63.71-137.88 2.3 D6MIT149 KS 22q11, 12p13, 12p11, 10q11, 7q36
6 NZxSM 59.7 125.7 94.82-137.84 2.3 D6MIT52 SM 12p13, 12p12-p11, 12q13
6 MRxSM 4.9 11.0 6.56-136.45 2.5 rs29926568 MR 7q21-q22, 7q31-q32
Chcmq6 12 C3xD 33.7 77.7 68.04-89.05 rs3700554 C3/D (M), D (F) 14q23-q24
Chcmq7 18 KSxSM 40.5 68.3 49.49-73.54 D18MIT208 SM (F) 18q21, 18p11
Chcmq8 11 BxD 70.9 107.8 94.65-113.41 rs13481179 D (F) 17q23-q24, 17q25
Chcmq9 9 KSxSM 38.7 69.6 56.85-110.67 D9MIT198 SM (M) 15q21, 15q21-q23
Chcmq10 8 MRxSM 8.7 16.9 16.86-131.24 rs13479624 MR (M), SM (F) 8p23-p22, 8p12, 8p11, 13q14
Chcmq11 9 CBy129SI 32.4 59.3 rs3685575 CBy (M) 11q23, 15q22, 15q23-q25
Chcmq12 8 129SIxA 31.9 64.9 34.25-128.56 rs3678134 129S1 (M) 4q31, 8p23-p21, 4q34, 4q31-q32, 4q33, 19p13-p12
Chcmq13 8 129S1xA 65.8 120.5 rs13479965 16q24, 16q22-qter, 1q42, 10p11
Chcmq14 14 129S1xA 34.6 67.6 rs13482140 8p21, 13q14
1 C3xD 41.8 81.7 66.58-195.10 2.4 rs3022821 C3 2q35, 2q33-q35, 2q35-q36
1 BxWSB 75.1 169.6 12.8-194.3 1.5 D1MIT16 WSB 1q31, 1q32, 1q25,
5 BxWSB 60.4 120.3 111.9-139.6 2.4 D5Mit367 WSB 22q12, 12q24, 22q11, 1p22, 12q24
9 BxWSB 14.4 28.4 28.4-75.7 1.6 D9MIT64 11q24, 11q24, 11q23
17 BxWSB 17.9 32.9 39.2-72.4 1.5 D17MIT175 WSB 19p13, 6p21, 21q22
15 CByx129SI 33.8 72.6 41.12-84.31 2.2 rs13482655 CBy 8q24, 8q23-q24
19 KSxSM 29.4 34.3 14.90-37.32 2.6 D1MIT88 KS 10q23, 10q25, 10q26

LOD scores are not given for sex-specific QTL, which are identified by the difference in LOD scores between sex-additive and sex-interactive scans (see “Methods”). LOD scores and 95% CIs are not given for QTL that interact significantly but by themselves are not significant.

*

QTL names are given for the cross in which each was first identified. Loci on the same chromosome identified in subsequent crosses may or may not be the same QTL (see text).

Megabase (Mb) positions (Build 37) were determined using the Center for Genome Dynamics (http://cgd.jax.org) Mouse Map Converter Tool.

Significant LOD score.

§

Homologous positions identified using Mouse Genome Informatics Mouse-Human Orthology Maps (http://www.informatics.jax.org).

QTL identified from pairwise search for gene interactions.

Sex-specific QTL: M, male; F, female.