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. 2010 Sep 10;116(25):e139–e149. doi: 10.1182/blood-2010-05-283879

Table 6.

Concordance of human GWAS for Hb, MCH, and MCHC, and Mouse CHCM QTL

Candidate gene(s) Human chr QTL cross Mouse Chr QTL peak position (Mb) CI (Mb) MGI gene location (Mb)
Abo 9 MRxSM 2 33.0 10.95-52.49 26.7
Tmprss6 22 CBy129S1 15 72.6 41.12-84.31 78.3
Cdt1 16 129S1xA (Chcmq13)* 8 120.5 125.1
March8-Anubl1-Fam21c 10 KSxSM 6 116.5 63.71-137.88 116.3
Ncaph2-Sco2-Tymp-Klhdc7b 22 CByx129S1 15 72.6 41.12-84.31 89.2
Rcl1 9 KSxSM 19 34.3 14.90-37.32 29.2
Gcdh 19 129S1xA (Chcmq12) 8 64.9 34.25-128.56 87.4
Spna1 1 C3xD 1 81.7 66.58-195.10 176.1
Aldh2 12 BxWSB 5 120.3 111.9-139.6 122.0
Trafd1 12 BxWSB 5 120.3 111.9-139.6 121.8
Bysl 6 BxWSB 17 32.9 39.2-72.4 47.7
*

QTL identified in pairwise search for gene interactions; Hb, hemoglobin; MCH, mean cell hemoglobin; MCHC, mean cell hemoglobin concentration; and CHCM, cell hemoglobin concentration mean.