. Author manuscript; available in PMC: 2011 Jan 31.

Published in final edited form as: Circ Cardiovasc Qual Outcomes. 2009 Oct 13;2(6):607–615. doi: 10.1161/CIRCOUTCOMES.109.869131

Table 3.

Temporal trends in angina and related characteristics at one year in consecutive PCI patients in the NHLBI-sponsored Dynamic Registry 1997–2004 cohorts

Characteristics	Wave 1 (1997)	Wave 2 (1999)	Wave 3 (2001)	Wave 4 (2004)	Wave 5 (2006)	Ptrend^*

	N=1793	N=1417	N=1379	N=1657	N=1657
Angina in past 6 weeks, %
Overall cohort	24	23	18	20	18	<0.001
By 1^° reason for initial PCI
Stable Angina	27	26	20	24	22	0.03
Unstable angina /AMI	25	23	19	21	19	<0.001
Asymptomatic CAD / Other	13	7	8	8	8	0.27
Mean (adjusted) QOL scores ^†	6.2	6.5	6.6	6.6	6.6	<0.001
Poor / Fair health status, %	28	32	29	30	31
Physical Activity, %						0.003
Sedentary	9	10	10	10	11
Mild	40	39	42	40	45
Moderate	43	45	41	42	38
Strenuous	7	7	7	9	6
Hospitalizations over 1 year, %
Death	4	5	4	4	4	0.64
Death/MI	9	10	8	9	8	0.20
Repeat PCI	16	13	12	10	10	<0.001
CABG	7	5	4	3	3	<0.001
One year medication use among those prescribed at discharge, %
Aspirin	81	80	74	82	87	<0.001
Lipid lowering medications	76	78	73	79	78	0.04
Antiplatelets ^‡	2	4	15	55	73	<0.001
ACE-Inhibitors	59	61	59	64	64	0.02
Beta blockers	75	75	70	76	78	0.03
Long-acting nitrates	51	40	37	43	47	0.08
Calcium channel blockers	58	59	51	52	60	0.50

	Among those with angina
	N=436	N=321	N=246	N=332	N=332

Severity of symptoms, %						0.06
Stable CHC I/II Angina	55	54	60	59	49
Stable CHC III/IV Angina	21	21	23	13	12
Unstable Angina/AMI	25	25	17	29	40
Frequency of symptoms,%						0.03
Three or more times/day	4	8	6	10	11
One to two times/day	13	10	14	13	11
Several times/week	31	31	39	31	30
Once/week or less	52	51	41	46	48
Sublingual NTG, %	76	68	64	61	59	<0.001

ACE: Angiotensin-converting enzyme inhibitors, ARB: Angiotensin-receptor blockers, CABG: coronary artery bypass grafting, MI: Myocardial infarction, NTG: Nitroglycerin, PCI: Percutaneous coronary intervention;

P_trend calculated using Cochran-Armitage test for dichotomous, Jonckeheere-Terpstra test for ordinal variables and Log rank test for cumulative hospitalization rates over one year:

^†

Test for trend done using linear contrasts (PROC GLM) adjusting for age, sex, race and concomitant comorbidities (history of diabetes, hypercholesterolemia, hypertension, congestive heart failure, severe non-cardiovascular diseases);

^‡

Information on 1-year Clopidogrel use not routinely collected in Waves 2 and 3