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. 2011 Feb 1;22(3):421–436. doi: 10.1091/mbc.e10-10-0807

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© 2011 Won et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 12: — Ca²⁺ in lobules following cerulein injection. (A–C) Representative Ca²⁺ signals evoked by the indicated agonists in periacinar cells from WT animals treated with cerulein for 1 wk as detailed in Materials and Methods. (D–F) Representative traces from LSL-K-Ras^G12D animals evoked by the indicated agonists following treatment with cerulein for 1 wk. (G–I) Pooled data representing the change in responsiveness of lobules to thrombin, trypsin, and ATP following treatment with cerulein. The numbers indicate the number of animals:number of lobules for which responses were observed/total number of lobules imaged.