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. 2011 Feb 1;22(3):421–436. doi: 10.1091/mbc.e10-10-0807

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© 2011 Won et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 4: — MP imaging of Ca²⁺ signals in pancreatic lobules. (A) A typical MP-imaging experiment is shown. (Aa) MP image of a lobule loaded with Fluo-4 AM. (A, b and c) ΔF/F₀ images before and after ATP exposure, respectively. (B) Representative [Ca²⁺]_i trace from a periacinar cell responding to ATP exposure. (C) A periacinar cell responds to bradykinin but not CCK (black trace) while an acinar cell in the same field responds to CCK (red trace). (D) Typical response to angiotensin. (E) A periacinar cell responds to CCh but not thrombin. (F) An acinar cell (red trace) but not a periacinar cell responds to trypsin exposure.