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. 2011 Jan 31;6(1):e14632. doi: 10.1371/journal.pone.0014632

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Tabach et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Using Ingenuity Pathway Analysis (IPA, see Methods), we summarized the known regulatory interaction of "cancer initiating genes" with the "potential regulator genes" and transcription factors (blue arrows). When no direct connection was found, we searched for indirect connections through mediator genes. If more than one such gene was found, we connected representative interactions (green arrow). Finally, we connected the genes in the lists to known cancer related pathways, based on the IPA database. First row: the list of "cancer initiating genes" which are located on 20q13. Second row: mediators - genes that have protein-protein interaction with the "cancer initiating genes" or are regulated by these genes and are also known regulators of the "potential regulator genes". Third row: The transcription factors that were found by POC. 4th row: the "potential regulator genes". 5th row: the list of cancer pathways as defined by IPA and the "potential regulator genes" from our analysis that belong to these pathways. We filtered out the"potential regulator genes" and transcription factors for which no direct or through one mediator connection to our "cancer initiating genes" were found.