Table 1. List of cases used for the FLIM-FRET study.
case # | APOE genotype | age at death | Sex | PMI (hrs) | ApoE NT, Aβ | ApoE CT, Aβ | ApoE CT, NT |
1 | ε3/3 | 88 | F | 12 | ✓ | ||
2 | ε3/3 | 83 | F | ✓ | ✓ | ||
3 | ε3/3 | 75 | F | ✓ | ✓ | ||
4 | ε3/3 | 88 | M | <12 | ✓ | ✓ | |
5 | ε3/3 | 87 | F | 4 | ✓ | ||
6 | ε3/3 | 82 | M | 9 | ✓ | ||
7 | ε3/3 | 73 | F | ✓ | |||
8 | ε3/3 | 82 | F | 7 | ✓ | ||
Total number of plaques | 20 | 20 | 14 | ||||
9 | ε4/4 | 78 | F | ✓ | ✓ | ✓ | |
10 | ε4/4 | 74 | M | 18 | ✓ | ✓ | |
11 | ε4/4 | 78 | M | 16 | ✓ | ✓ | |
12 | ε4/4 | 68 | F | 23 | ✓ | ||
13 | ε4/4 | 81 | M | ✓ | |||
14 | ε4/4 | 84 | F | ✓ | |||
15 | ε4/4 | 84 | M | 24 | ✓ | ||
16 | ε4/4 | 80 | F | 10 | ✓ | ||
17 | ε4/4 | ✓ | |||||
Total number of plaques | 19 | 25 | 22 |
The genotype, age of the patient at death, sex and postmortem interval (PMI) is given where available from ADRC records. The check marks show which of the three experiments in which the brain was used. Some brains were used in more than one comparison depending on availability of tissue. For each of the 6 comparisons, the total number of plaques imaged (‘n’) is also given.