. 2011 Jan 31;6(1):e15809. doi: 10.1371/journal.pone.0015809

Table 2. Differentially-expressed protein molecules in CSF of Huntington's disease (HD) patients.

Up-regulated proteins in CSF of patients with HD identified by MALDI-TOF MS
Spot^a)	Accession No.^b)	Protein name	pI/M.W.	Score^c)	Coverage^d) (%)	Mean of fold changes^e) (HD/C)	Frequency^f), P value
1	P00734	Prothrombin	5.64/69209	82	23	1.66	5/6, P = 0.03
2	P06727	Apolipoprotein A-IV	5.28/45371	174	42	1.67	4/6, P = 0.04

^a)

Spots numbered as shown in Figure 1.

^b)

The accession numbers on SWISS-PROT database.

^c)

The MASCOT search score of identified proteins.

^d)

The percentage of sequence coverage of matched peptides in the identified protein.

^e)

The mean protein expression level in the HD patients over that in the controls in Figure 1C.

^f)

The frequency of the target protein, for which the expression ratio of HD/C was >1.5. P<0.05 indicates a significant difference in expression levels between HD patients and controls analyzed by paired student's t-test.