Skip to main content
. 2011 Jan 31;6(1):e15924. doi: 10.1371/journal.pone.0015924

Figure 3. HIV Controllers Have High Frequencies of CMV-specific T Cells.

Figure 3

(A) The frequency of CD4+ T cells producing IFN-γ after incubation with CMV pp65 peptides in vitro (representative flow plot depicted in Figure 1 from reference [85]) was assessed in HIV-uninfected but CMV-seropositive controls, HIV controllers, and untreated HIV-infected participants with varying degrees of detectable viremia (75–2000, 2001–10,000, and >10,000 copies/ml). The HIV controllers had higher CMV pp65-specific IFN-bright CD4+ T cell responses than HIV-uninfected controls and HIV-infected participants with high levels of viremia. HIV controllers with higher CMV pp65-specific CD4+ T cell responses also had higher HIV Gag-specific CD4+ T cell responses (curve represents linear regression model on untransformed data, B).