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. 2011 Jan 31;6(1):e15924. doi: 10.1371/journal.pone.0015924

Figure 4. Theoretical Model to Describe Positive and Negative Consequences of Low Treg Frequencies in HIV Controllers.

Figure 4

A theoretical model to describe the potential positive and negative consequences of low Treg frequencies in HIV controllers is presented. While a low Treg response might increase HIV-specific T cell responses, contributing to the clearance of HIV-infected cells and the maintenance of extremely low levels of viral replication, a low Treg response might also increase generalized T cell activation, contributing to CD4+ T cell decline and other inflammation-associated comorbidities even in the presence of very low levels of viral replication.