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. 2011 Jan 31;6(1):e16414. doi: 10.1371/journal.pone.0016414

Figure 1. Diagram of the ITvar9 PfEMP1 variant showing domains expressed as recombinant proteins in E.coli.

Figure 1

The ITvar9 gene (also known as R29var1 [9], accession numbers Y13402 and CAA73831) encodes a group A PfEMP1 variant with four Duffy Binding Like (DBL) and two Cysteine-rich InterDomain Region (CIDR) domains. The number of the domain designates its position from the N-terminus and the Greek symbol represents its homology group [64]. PfEMP1 contains a N-Terminal Segment (NTS) and an Acidic Terminal Segment (ATS) proximal to the transmembrane (TM) region. The DBL1α domain is the functional erythrocyte-binding region [9]. The bars represent the E.coli expression constructs and the numbers show the first and last amino acid positions.