Table 3. Mean mutant frequency, mean genetic distance and dS and dN (x100 sites) of the HCV plasma quasispecies in 10 patients included in the analysis at different times.
| E1/E2 | HVR-1 | ||||||
| Group | Time | M.f. (±SD) | G. d (±SD) | M.f. (±SD) | G. d (±SD) | dS (±SD) | dN (±SD) |
| A | T0 | 0.27 (0.1) | 0.4 (0.3) | 0.18 (0.06) | 0.86 (0.7) | 0.7 (1.0) | 0.44 (0.3) |
| T1 | 0.79 (0.09) | 3.1 (2.7) | 0.6 (0.2) | 8.1 (8.5) | 4.5 (3.4) | 7.4 (3.4) | |
| pa | 0.04 | 0.04 | 0.04 | 0.04 | 0.04 | 0.07 | |
| B | T0 | 0.36 (0.26) | 0.7 (0.5) | 0.32 (0.14) | 0.87 (0.6) | 1.4 (1.0) | 0.2 (0.2) |
| T1 | 0.40 (0.26) | 1.8 (2.1) | 0.27 (0.12) | 5.9 (7.2) | 0.8 (0.9) | 2.3 (0.6) | |
| pa | 0.593 | 0.285 | 1.0 | 0.1 | 0.1 | 0.6 | |
| C | T0 | 0.6 | 3.6 | 0.4 | 5.6 | 5.8 | 5.5 |
| T1 | 0.6 | 4.1 | 0.5 | 3.3 | 6.0 | 2.1 | |
| pa | 1.0 | 0.6 | 0.6 | 0.6 | 0.6 | 0.6 | |
M.f. = mutant frequency (mutant clones/total clones).
G.d = Genetic distance.
dS/dN = synonymous/non-synonymous substitutions.
SD = standard deviation.
T0 = Baseline.
T1 = Post-treatment: the latest post treatment values.
pa = level of significance comparing T0 and T1 by Wilcoxon's test.