Table 4. Mean evolutionary rate estimates (x10−3) and 95%HPD for whole E1/E2 sequences and separate codon positions (1st +2nd and 3rd) and root tMRCAs (in months before the last sample) and months of follow-up in 8 patients and 2 controls.
Patient | M.E.R. (95%HPD) | R.E.R.1st+2nd (95%HPD) | R.E.R. 3rd (95%HPD) | R.tMRCA (95%HPD) | Months |
# 1 | 1.9 (1.1–2.9) | 0.9 (0.7–1.2) | 1.1 (0.6–1.6) | 36.9 (36–38) | 36 |
# 2 | 0.6 (0.2–1.1) | 0.9 (0.6–1.2) | 1.2 (0.6–1.8) | 37.2 (27–53) | 26 |
# 3 | 2.0 (0.4–3.4) | 1 (0.7–1.3) | 1.0 (0.5–1.5) | 33.3 (20–70) | 24 |
# 4 | 1.0 (0.5–1.6) | 0.8 (0.5–1.1) | 1.4 (0.9–2.0) | 43.7 (39–50) | 39 |
# 5 | 2.1 (1.3–2.9) | 1.1 (0.8–1.3) | 0.9 (0.5–1.3) | 33.6 (33–34) | 33 |
# 6 | 2.8 (1.7–4.2) | 1 (0.8–1.2) | 0.99 (0.6–1.4) | 22.9 (21–25) | 20 |
# 7 | 0.17 (0.03–0.3) | 1.1 (0.7–1.3) | 0.9 (0.3–1.5) | 78.0 (35–144) | 30 |
# 8 | 2.3 (0.9–3.7) | 1.2 (0.9–1.5) | 0.6 (0.1–1.6) | 14.5 (14–15) | 14 |
# 9 | 0.37 (0.15–0.6) | 0.4 (0.2–0.6) | 2.2 (1.8–2.6) | 76.8 (52–119) | 48 |
# 10 | 0.22 (0.06–0.4) | 0.9 (0.6–1.1) | 1.3 (0.7–1.9) | 295.9 (137–525) | 82 |
Group A: Subjects #1-5; group B: Subjects #6-8; group C (controls): Subjects #9 and 10.
E.R. = Evolutionary rate estimates in substitution/site/year.
R.tMRCA = Tree root time (months before the most recent sample).
M.E.R. = Mean evolutionary rate.
R.E.R. = Relative evolutionary rate.