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. 2011 Jan 31;6(1):e16598. doi: 10.1371/journal.pone.0016598

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Sarkari et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) CNE2 cells expressing the indicated individual PML isoforms were treated with siRNA against USP7 (siUSP7) or negative control siRNA (siC). Cells were then fixed and stained for USP7 and PML and counter stained with DAPI. Images using the same antibody were captured with the same exposure times. (B) The number of PML NBs per cell were counted for 100 cells for each of the samples in (A). Average numbers are shown with standard deviations calculated from 3 independent experiments. P values between the control and siUSP7 samples are 0.001 for PML I, 0.1 for PML II, 0.01 for PML IV, 0.2 for PML V and 0.5 for PML VI.