Table 1.
Demographic and clinical characteristics measured at DCCT Baseline by OxLDL-IC Tertile Grouping. Continuous characteristics are denoted as mean ± standard deviation and categorical characteristics are denoted as n (%).
| OxLDL-IC Tertiles |
P-Value | |||
|---|---|---|---|---|
| 1 | 2 | 3 | ||
| n=158 | n=159 | n=159 | ||
| Age (yrs) | 26.9 ± 6.9 | 27.5 ± 6.6 | 27.3 ± 7.4 | 0.751 |
| BMI (kg/m2) | 23.0 ± 2.8 | 23.5 ± 2.5 | 23.8 ± 3.2 | 0.067 |
| Duration of T1D (yrs) | 5.5 ± 4.1 | 5.6 ± 4.2 | 6.5 ± 4.2 | 0.031 |
| DCCT Follow up (yrs) | 6.1 ± 1.6 | 6.4 ± 1.8 | 6.9 ± 1.8 | 0.001 |
| EDIC Follow up (yrs) | 9.0 ± 0.5 | 9.1 ± 0.5 | 9.1 ± 0.5 | 0.196 |
| SBP (mmHg) | 113.2 ± 11.5 | 115.0 ± 11.0 | 115.6 ± 11.0 | 0.123 |
| DBP (mmHg) | 72.7 ± 9.0 | 72.5 ± 9.2 | 74.3 ± 8.7 | 0.054 |
| MAP (mmHg) | 86.2 ± 9.0 | 86.7 ± 8.6 | 88.1 ± 8.5 | 0.051 |
| Cholesterol (mg/dl) | 169.5 ± 29.7 | 171.5 ± 35.1 | 183.3 ± 32.7 | <0.001 |
| HDL (mg/dl) | 53.4 ± 12.9 | 49.9 ± 11.7 | 49.0 ± 11.9 | 0.004 |
| LDL (mg/dl) | 101.8 ± 26.6 | 106.1 ± 30.8 | 116.5 ± 28.2 | <0.001 |
| Trig (mg/dl) | 72.2 ± 31.1 | 77.6 ± 38.9 | 89.2 ± 44.7 | <0.001 |
| HbA1C % | 8.8 ± 1.5 | 8.7 ± 1.6 | 9.1 ± 1.7 | 0.088 |
| AER (mg/24 Hrs) | 14.9 ± 13.5 | 15.8 ± 21.6 | 18.0 ± 17.8 | 0.022 |
| Serum Creatinine | 0.81 ± 0.16 | 0.80 ± 0.14 | 0.80 ± 0.15 | 0.536 |
| Intensive Treatment, n (%) | 82 (51.9) | 77 (48.4) | 58 (36.5) | 0.015 |
| Primary Ret Cohort | 75 (47.5) | 83 (52.2) | 55 (34.6) | 0.005 |
| Male | 70 (44.3) | 86 (54.1) | 93 (58.5) | 0.035 |
| Smoker (current at BL) | 29 (18.4) | 36 (22.6) | 35 (22.0) | 0.600 |
| Drinker (current at BL) | 35 (22.2) | 24 (15.1) | 34 (21.4) | 0.220 |
BMI = Body Mass Index, SBP = Systolic Blood Pressure, DBP = Diastolic Blood Pressure, MAP = Mean Arterial Pressure, HDL = High-Density Lipoprotein Cholesterol, LDL = Low-Density Lipoprotein, Trig = triglycerides, AER = Albumin Excretion Rate
†
Continuous measures are compared with Wilcoxon Ranks Sum statistics. Pearson Chi Square statistics are used for Categorical measures.