Table 2.
Demographic and clinical characteristics measured at DCCT Baseline by CAC Grouping. Continuous characteristics are denoted as mean ± standard deviation and categorical characteristics are denoted as n (%).
| DCCT Baseline Characteristic (Mean±SE) | Overall N=476 |
CAC Groupings | P-Value | |
|---|---|---|---|---|
| 0 – 100 n=407 |
> 100 n=69 |
|||
| Age (yrs) | 27.2 ± 7.0 | 26.5 ± 6.8 | 31.7 ± 5.9 | <0.001 |
| BMI(kg/m2) | 23.5 ± 2.8 | 23.3 ± 2.8 | 24.4 ± 3.1 | 0.009 |
| Duration of T1D (yrs) | 5.8 ± 4.1 | 5.7 ± 4.1 | 6.9 ± 4.5 | 0.036 |
| SBP (mmHg) | 114.6 ± 11.2 | 114.0 ± 11.3 | 117.9 ± 10.3 | 0.009 |
| DBP (mmHg) | 73.2 ± 9.0 | 73.1 ± 9.1 | 73.9 ± 8.1 | 0.431 |
| MAP (mmHg) | 87.0 ± 8.7 | 86.7 ± 8.8 | 88.5 ± 7.9 | 0.090 |
| Cholesterol (mg/dl) | 174.8 ± 33.1 | 172.1 ± 32.2 | 190.7 ± 34.0 | <0.001 |
| HDL (mg/dl) | 50.7 ± 12.3 | 51.2 ± 12.4 | 47.9 ± 11.3 | 0.056 |
| LDL (mg/dl) | 108.1 ± 29.2 | 105.2 ± 28.1 | 125.7 ± 29.6 | <0.001 |
| Trig (mg/dl) | 79.7 ± 39.2 | 78.6 ± 39.4 | 85.9 ± 37.8 | 0.067 |
| HbA1C % | 8.9 ± 1.6 | 8.8 ± 1.6 | 9.0 ± 1.7 | 0.463 |
| AER (mg/24 Hrs) | 16.3 ± 17.9 | 15.7 ± 15.6 | 19.8 ± 28.1 | 0.180 |
| Serum Creatinine | 0.80 ± 0.15 | 0.80 ± 0.15 | 0.81 ± 0.15 | 0.507 |
| OxLDL-IC at DCCT Entry (mg/L) | 5.03 ± 0.91 | 4.98 ± 0.92 | 5.38 ± 0.81 | <0.001 |
| Intensive Treatment, n (%) | 217 (45.6) | 189 (46.4) | 28 (40.6) | 0.366 |
| Primary Ret Cohort | 213 (44.8) | 189 (46.4) | 24 (34.8) | 0.072 |
| Male | 249 (52.3) | 200 (49.1) | 49 (71.0) | <0.001 |
| Smoker (current at BL) | 100 (21.0) | 73 (17.9) | 27 (39.1) | <0.001 |
| Drinker (current at BL) | 93 (19.5) | 77 (18.9) | 16 (23.2) | 0.406 |
BMI = Body Mass Index, SBP = Systolic Blood Pressure, DBP = Diastolic Blood Pressure, MAP = Mean Arterial Pressure, HDL = High-Density Lipoprotein Cholesterol, LDL = Low-Density Lipoprotein, Trig = triglycerides, AER = Albumin Excretion Rate
†
Continuous measures are compared with Wilcoxon Ranks Sum statistics. Pearson Chi Square statistics are used for Categorical measures.