Figure 1.

Hierarchical clustering of the cytogenetic subtypes of pediatric AML by gene expression profiling. (A) Hierarchical clustering of 157 patients in the discovery cohort by gene expression signature derived from 75 classifying probe sets (Online Supplementary Table S2). (B) Validation of the gene expression pattern in 80 patients of the independent validation cohort (C) MLL-rearranged AML cases do not separate into distinct clusters based on similarity in expression pattern related to the translocation partner using the 75 classifying probe sets.