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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: Pharmacol Res. 2010 Nov 18;63(2):146–150. doi: 10.1016/j.phrs.2010.11.003

Fig 1. CMT-3 Inhibition of experimental prostate cancer metastasizing to bone and lung in the Dunning MAT-LyLu model.

Fig 1

The MAT Ly Lu tumor cells were injected i.v following vena cava clamping with a mini surgical bulldog clamp. As described in the text, animals were orally dosed with CMT-3 or vehicle -7 days (Group 1),+ 1 day (Group 2), or +3 days (Group 3) and vehicle-only (Group 4) [Panel B]. In an independent experiment, MAT LyLU cells transfected with EGFP were injected as shown in Fig. 1A and were detected as dispersed in femoral bones (Fig. 1C and D). Cells isolated from marrow plugs were cultured to confirm tumor cells (data not shown).