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. Author manuscript; available in PMC: 2012 Feb 4.
Published in final edited form as: Org Lett. 2010 Dec 21;13(3):394–397. doi: 10.1021/ol102682r

Table 1.

Optimization of the enantioselective arylation of N-Boc-2-lithiopiperidine by CDR.

graphic file with name nihms260166t1.jpg
entry (S,S)-2
(mol %)		 time (h) solvent yield (%)
of 3		 er of 3
(R:S)
1 10 3 Et2O 74 90:10
2 10 3 MTBE 65 86:14
3 5 3 Et2O 70 93:7
4 5 5 Et2O 68 96:4
5 5 5 MTBE 60 89:11
6 100 3 Et2O 71 53:47