Fig. 5.

3D model and domain organization of CGI-58. A homology model of CGI-58 was built using Swiss-Model based on Aspergillus niger epoxide hydrolase as template [204,205]. The compact αβα sandwich containing the α/β-hydrolase core structure is depicted as cartoon in rainbow colors; residues of the putative catalytic triad in corresponding hydrolases are highlighted as yellow sticks (Asn155, His329, Asp303). The cap region covering the potential active site is depicted in magenta, whereas the N-terminal extension is depicted as a grey ribbon. N- and C-termini are indicated with capital letters. The figure was prepared using PyMol (The PyMOL Molecular Graphics System, Version 1.2, Schrödinger, LLC).