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. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: Neuroimage. 2010 Nov 30;55(1):32–38. doi: 10.1016/j.neuroimage.2010.11.073

Figure 1.

Figure 1

Metal ion content in the cortex in PSAPP (colored bars) and CNT mice (white bars). (A) Fe content in the cortex of PSAPP mice was altered from the beginning stages of plaque formation and was significantly higher in PSAPP mice than CNT mice at 24 weeks (PSAPP = 0.79 ± 0.18; CNT = 0.57 ± 0.05), 40 weeks (PSAPP = 1.01 ± 0.26; CNT = 0.60 ± 0.07), and 56 weeks (PSAPP = 0.79 ± 0.18; CNT = 0.60 ± 0.04). Fe content also significantly increased by 71% from 13 weeks-old to 40 weeks-old and by 34% from 13 weeks-old to 56 weeks-old. (B) Zn content in PSAPP mice increased from 13 weeks to 56 weeks and was also 161% higher than CNT mice at 56 weeks. (C) Cu remained constant in both the CNT and PSAPP mice. [Error bars = SD. * indicates significantly different from 13 week-old PSAPP mice (p < 0.05); # indicates significantly different from CNT mice at the same time point (p < 0.05).]