Table 1.
ROI | 13 weeks | 24 weeks | 40 weeks | 56 weeks |
---|---|---|---|---|
Total | ||||
Hippocampus | ||||
PSAPP | 260 ± 29 (N = 6) |
341 ± 31* (N = 5) |
369 ± 89 (N = 6) |
291 ± 15‡,# (N = 5) |
CNT | 299 ± 54 (N = 6) |
380 ± 122 (N = 6) |
300 ± 74 (N = 7) |
354 ± 21 (N = 7) |
Dendritic Layer | ||||
PSAPP | 249 ± 27 | 324 ± 32* | 352 ± 85 | 280 ± 13‡,# |
CNT | 288 ± 53 | 360 ± 122 | 285 ± 70 | 342 ± 21 |
PCL | ||||
PSAPP | 468 ± 37 | 710 ± 71* | 688 ± 181 | 468 ± 68‡,# |
CNT | 546 ± 81 | 880 ± 246 | 649 ± 200 | 726 ± 96 |
CA3 | ||||
PSAPP | 225 ± 29 | 294 ± 22* | 346 ± 88 | 291 ± 43 |
CNT | 265 ± 69 | 345 ± 117 | 244 ± 57 | 395 ± 19 |
Hilus | ||||
PSAPP | 237 ± 28 | 281 ± 24 | 343 ± 71* | 326 ± 31*, # |
CNT | 265 ± 55 | 335 ± 98 | 242 ± 50 | 270 ± 19 |
Cortex | ||||
PSAPP | 590 ± 40 | 790 ± 180 | 1010 ± 260* | 790 ± 180*, # |
CNT | 570 ± 10 | 570 ± 50 | 600 ± 70 | 600 ± 40 |
significantly different from 13 weeks
significantly different from 24 weeks
significantly different from CNT