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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: J Am Chem Soc. 2009 Dec 9;131(48):17605–17614. doi: 10.1021/ja905767g

Figure 1.

Figure 1

(a) Binding of aminoglycosides to the bacterial A-site impacts the placement and dynamics of the unpaired A1492 and 1493 residues. (b) By replacing one of the nucleosides in the A-site with an isosteric emissive nucleoside analogue as a donor (D) and tagging the antibiotics with an appropriate acceptor (A), binding and displacement events can be accurately monitored using FRET.