Fig. 4.
Effects of sulfasalazine, S-4-CPG, and 5-ASA on glioma cell growth. U-87MG cells were incubated with various concentrations of sulfasalazine, S-4-CPG, or 5-ASA for 24 h (a), 48 h (b), and 72 h (c). At the end of incubations, cell numbers were determined and compared with that of untreated sister cultures. While each of the system xc− inhibitors sulfasalazine and S-4-CPG inhibited cell growth of U-87MG, the NF-κB inhibitor, 5-ASA, did not affect cell growth. Error bars indicate SE. All experiments were carried out with n = 6.