Table 3. Association between total number of risk alleles and colorectal cancer risk.
| Total no. of risk alleles | Cases No. (%) | Controls No. (%) | OR (95% CI) | |
|---|---|---|---|---|
| 4–6 | 25 (3.6) | 42 (5.9) | 0.54 (0.32–0.94) | |
| 7 | 39 (5.6) | 76 (10.7) | 0.47 (0.30–0.74) | |
| 8 | 101 (14.4) | 131 (18.5) | 0.70 (0.50–1.00) | |
| 9 | 160 (22.8) | 128 (18.1) | 1.14 (0.82–1.59) | |
| 10 | 151 (21.4) | 138 (19.5) | 1.0 (reference) | |
| 11 | 110 (15.7) | 104 (14.7) | 0.97 (0.68–1.38) | |
| 12 | 77 (11.0) | 61 (8.5) | 1.15 (0.77–1.73) | |
| 13–15 | 39 (5.5) | 29 (4.1) | 1.23 (0.72–2.09) | |
| Ptrend=2.29 × 10−5 |
Abbreviations: CI=confidence intervals; OR=odds ratio; SNP=single-nucleotide polymorphism.
SNPs used to calculate number of risk alleles: rs7014346, rs10795668, rs3802842, rs4444235, rs4779584, rs9929218, rs12953717, rs10411210 and rs355527.
High-risk allele: more frequent allele observed in cases from reference study.
P – obtained from χ2 test.
Ptrend – obtained from Cochrane–Armitage trend test.