Table 5. Heterogeneity of associations between Hong Kong Han Chinese population and other populations.

	OR (95% CI), high-risk allele frequency in control subjects; ref allele: low-risk allele in this study				Breslow–Day's test Pheterogeneity with this study
SNP, chromosome	HK	England/CEU	Japan	Scotland	England/CEU	Japan	Scotland	Reference
rs7014346, 8q24.21	1.23 (1.05–1.44), 30%	1.29 (1.18–1.40), 36%	0.85 (0.79–0.92), 77%a	1.23 (1.15–1.33), 37%	0.60	3.67 × 10–5	0.95	Tenesa et al (2008)
rs10795668, 10p14	1.28 (1.1–1.5), 62%	1.12 (1.00–1.25), 67%	—		0.17			Tomlinson et al (2008)
rs4779584, 15q14	1.26 (1.04–1.52), 79%	1.21 (1.12–1.31), 19%a	—		0.72			Jaeger et al (2008)
rs12953717, 18q21.2	1.20 (1.03–1.40), 33%	1.38 (1.21–1.56), 42%	—		0.19			Broderick et al (2007)
rs4939827, 18q21.2	1.17 (1.01–1.37), 35%	1.40 (1.23–1.59), 51%a	—		0.08			Broderick et al (2007)
rs10318, 15q14	1.10 (0.95–1.27), 44%	0.79 (0.67–0.94), 82%a	—		0.005			Jaeger et al (2008)
rs4464148, 18q21.2	1.20 (1.03–1.4), 33%	1.35 (1.18–1.55), 29%	—		0.29			Broderick et al (2007)
rs12953717, 15q14	1.2 (1.03–1.4), 33%	1.38 (1.21–1.56), 42%	—		0.19			Broderick et al (2007)
rs6983267, 8q24.21	1.12 (0.97–1.3), 43%	1.41 (1.24–1.6), 49%	—		0.02			Tomlinson et al (2007)
rs4444235, 14q22.3	1.02 (0.88–1.18), 48%	0.89 (0.85–0.93), 54%a	—		0.21			Houlston et al (2008)
rs9929218, 16q22.1	1.00 (0.84–1.18), 76%	1.14 (1.08–1.21), 70%	—		0.15			Houlston et al (2008)
rs355527, 20p12.3	1.10 (0.84–1.45), 7%	1.13 (1.08–1.19), 33%	—		0.85			Houlston et al (2008)
rs10411210, 19q12	1.02 (0.85–1.24), 82%	1.27 (1.16–1.38), 90%	—		0.045			Houlston et al (2008)

Abbreviations: CEU=Caucasian European; CI=confidence interval; CRC=colorectal cancer; HK=Hong Kong; OR=odds ratio; SNP=single-nucleotide polymorphism.

^aHigh-risk allele different in this and reference study.