Table 2. Biomarker test (CA-IX, HPV and CA-IX+HPV) results by histological diagnosis.
|
Histological diagnosis
|
|||||
|---|---|---|---|---|---|
| Biomarker test | Insignificant cervical lesions | SLs | GLs | All SCLs (SLs+GLs) | |
| Total numbera | 88 (%) | 51 (58) | 15 (17) | 22 (25) | 37 (42) |
| CA-IX | |||||
| Negative | 28 (32) | 24 (47) | 4 (27) | 0 | 4 (11) |
| Positive | 60 (68) | 27 (53)b | 11 (73) | 22 (100) | 33 (89) |
| Total numberc | 84 (%) | 50 (59) | 15 (18) | 19 (23) | 34 (40) |
| CA-IX | |||||
| Negative | 47 (56) | 43 (86) | 4 (27) | 0 | 4 (12) |
| Positive | 37 (44) | 7 (14) | 11 (73) | 19 (100) | 30 (88) |
| HPV (PCR) | |||||
| Negative | 55 (55) | 43 (51) | 3 (20) | 9 (47) | 12 (35) |
| Positive | 29 (35) | 7 (14)b | 12 (80) | 10 (53) | 22 (65) |
| CA-IX+HPV | |||||
| Negative | 22 (26) | 21 (42) | 1 (7) | 0 | 1 (3) |
| Positive | 62 (74) | 29 (58) | 14 (93) | 19 (100) | 33 (97) |
Abbreviations: AIS=adenocarcinoma in situ; CA-IX=carbonic anhydrase IX; CIN=cervical intraepithelial neoplasia; GL=glandular lesion; HPV=human papillomavirus; SCL=significant cervical lesion; SL=squamous lesion.
Insignificant cervical lesions, including negative/benign, CIN1, atypia and glandular hyperplasia; SLs: CIN2, CIN3 and squamous cell carcinoma; GLs: AIS and adenocarcinoma.
a
All cases tested for CA-IX.
b
Including two CIN1, one atypia and one hyperplasia.
c
Cases in which HPV (HC2) results were available.