Table 3. Diagnostic accuracy of CA-IX, HPV and CA-IX+HPV.
|
Sensitivity
|
||||||||
|---|---|---|---|---|---|---|---|---|
| Numbers tested | Biomarkers | SCLs | SLs | GLs | Specificity | NPV | PPV | FNR a |
| 88 | CA-IX | 0.89 | 0.73 | 1.00 | 0.47 | 0.86 | 0.55 | 0.14 |
| 84 | CA-IX | 0.88 | 0.73 | 1.00 | 0.50 | 0.86 | 0.54 | 0.14 |
| HPV (PCR) | 0.65 | 0.80 | 0.53 | 0.86 | 0.78 | 0.76 | 0.22 | |
| HPV (PCR)+CA-IX | 0.97 | 0.93 | 1.00 | 0.42 | 0.95 | 0.53 | 0.05 | |
Abbreviations: CA-IX=carbonic anhydrase IX; FNR=false negative rate; GL=glandular lesion; HPV=human papillomavirus; NPV=negative predictive value; PPV=positive predictive value; SCL=significant cervical lesion; SL=squamous lesion
a
FNR: defined as 1 NPV to reflect the proportion of negative diagnosis that was incorrect.