Table 3. Non-haematologic toxicities observed during chemoradiotherapy and within 2 weeks after completion, and considered possibly, probably or definitely related to treatment (NCI-CTC Version 2, 30 April 1999).
|
Dose level
|
||||||||
|---|---|---|---|---|---|---|---|---|
| Toxicity | Worst grade | 1 (n=6) | 2 (n=6) | 3 (n=3) | 4 (n=3) | 5 (n=3) | 6 (n=3) | Total (%) |
| Within radiotherapy field | ||||||||
| Dysphagia | 3 | 2 | 3 | 1 | 0 | 2 | 1 | 9 (37.5) |
| Outside radiotherapy field | ||||||||
| Anorexia | 3 | 0 | 1 | 0 | 0 | 0 | 0 | 1 (4.2) |
| Nausea | 3 | 0 | 2 | 0 | 0 | 0 | 1 | 3 (12.5) |
| Constipation | 3 | 1 | 0 | 1 | 0 | 0 | 1 | 3 (12.5) |
| Fatigue | 3 | 1 | 1 | 2 | 0 | 0 | 0 | 4 (16.7) |
| Fever | 3 | 1a | 0 | 0 | 0 | 0 | 0 | 1 (4.2) |
| Biochemical | ||||||||
| Hyperglycaemia | 3 | 0 | 1 | 0 | 0 | 0 | 0 | 1 (4.2) |
| Hyponatraemia | 3 | 0 | 1 | 0 | 0 | 1 | 0 | 2 (8.3) |
| Elevated GGT | 4 | 2b | 0 | 0 | 0 | 1 | 0 | 3 (12.5) |
a
Without neutropenia.
b
One patient in DL1 experienced grade 4 elevation of GGT, attributed to penicillin antibiotics, and reversed on their cessation.