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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Biochemistry. 2009 May 26;48(20):4377–4387. doi: 10.1021/bi9002056

Table 7.

Free energy enhancements (ΔΔG°37 kcal/mol) when LNA is substituted for an 2'-O-methyl 3'-dangling end.

X
X = DM/L X = AM/L X = GM/L X = UM/L X = CM/L
---AMX 0.8 0.6 0.5 0.2 0.1
---U
---UMX 1.4 1.2 1.0 0.3 0.5
---A
---GMX 1.2 0.9 1.2 0.3 0.4
---C
---CMX 0.7 0.9 1.6 0.3 0.7
---G