Table 1.
Results of GO analysis for age and CR
| Effect of Age | Effect of CR | ||||||
|---|---|---|---|---|---|---|---|
| CA1 | |||||||
| GO category | GO ID | GO Term | Ratio | GO category | GO ID | GO Term | Ratio |
| CC | 42613 | MHC class II protein complex | 4.46 | CC | 5891 | voltage-gated calcium channel complex | 6.76 |
| MF | 16527 | brain-specific angiogenesis inhibitor activity | 7.14 | MF | 8191 | metalloendopeptidase inhibitor activity | 19.67 |
| BP | 45582 | positive regulation of T cell differentiation | 4.45 | BP | 19233 | sensory perception of pain | 7.07 |
| BP | 30330 | DNA damage response, signal transduction by p53 class mediator | 4.45 | ||||
| CA3 | |||||||
| CC | 30864 | cortical actin cytoskeleton | 3.24 | CC | 35253 | ciliary rootlet | 6.99 |
| MF | 16527 | brain-specific angiogenesis inhibitor activity | 10.35 | MF | 5093 | Rab GDP-dissociation inhibitor activity | 9.9 |
| MF | 4757 | sepiapterin reductase activity | 10.35 | MF | 4740 | [pyruvate dehydrogenase (lipoamide)] kinase activity | 9.9 |
| BP | 48145 | regulation of fibroblast proliferation | 4.96 | BP | 6613 | cotranslational protein targeting to membrane | 4.96 |
| DG | |||||||
| CC | 5802 | trans-Golgi network | 3.88 | CC | 35253 | ciliary rootlet | 4.03 |
| MF | 4757 | sepiapterin reductase activity | 15.99 | MF | 4965 | GABA-B receptor activity | 7.23 |
| BP | 15802 | basic amino acid transport | 8.22 | MF | 4740 | [pyruvate dehydrogenase (lipoamide)] kinase activity | 7.23 |
| BP | 6596 | polyamine biosynthetic process | 4.95 | ||||
| Hippocampus | |||||||
| CC | 42613 | MHC class II protein complex | 3.34 | CC | 35253 | ciliary rootlet | 3.07 |
| CC | 30669 | clathrin-coated endocytic vesicle membrane | 3.34 | MF | 4965 | GABA-B receptor activity | 4.32 |
| CC | 30666 | endocytic vesicle membrane | 3.34 | MF | 4658 | propionyl-CoA carboxylase activity | 4.32 |
| CC | 30128 | clathrin coat of endocytic vesicle | 3.34 | MF | 4133 | glycogen debranching enzyme activity | 4.32 |
| CC | 30122 | AP-2 adaptor complex | 3.34 | MF | 4069 | aspartate transaminase activity | 4.32 |
| CC | 5666 | DNA-directed RNA polymerase III complex | 3.34 | BP | 6573 | valine metabolic process | 4.51 |
| MF | 16783 | sulfurtransferase activity | 3.35 | ||||
| MF | 16527 | brain-specific angiogenesis inhibitor activity | 3.35 | ||||
| MF | 8526 | phosphatidylinositol transporter activity | 3.35 | ||||
| MF | 4965 | GABA-B receptor activity | 3.35 | ||||
| MF | 4757 | sepiapterin reductase activity | 3.35 | ||||
| MF | 4558 | alpha-glucosidase activity | 3.35 | ||||
| MF | 4430 | 1-phosphatidylinositol 4-kinase activity | 3.35 | ||||
| MF | 4392 | heme oxygenase (decyclizing) activity | 3.35 | ||||
| MF | 4111 | creatine kinase activity | 3.35 | ||||
| MF | 3994 | aconitate hydratase activity | 3.35 | ||||
| BP | 19430 | removal of superoxide radicals | 3.53 | ||||
| BP | 6788 | heme oxidation | 3.53 | ||||
| BP | 1678 | cell glucose homeostasis | 3.53 | ||||
| BP | 389 | nuclear mRNA 3′-splice site recognition | 3.53 | ||||
For each category; cellular component (CC), molecular function (MF), and biological process (BP), the gene ontology groups with the largest observed/expected ratio (Ratio) are identified according to the GO ID and term.