Table 2.
Pathways Altered by Caloric Restriction or Aging in the Hippocampus
| Aging |
Caloric Restriction |
||||||
|---|---|---|---|---|---|---|---|
| Pathway | P | Ratio | FC | Pathway | P | Ratio | FC |
|
CA1 | |||||||
| Estrogen Receptor Signaling | 0.000567 | 0.178 | +18,−3 | Synaptic Long Term Potentiation | 0.00635 | 0.054 | +5, −1 |
| NRF2-mediated Oxidative Stress Response | 0.000586 | 0.167 | +24, −6 | Neuregulin Signaling | 0.00927 | 0.055 | +2, −3 |
| Huntington’s Disease Signaling | 0.000994 | 0.147 | +29, −5 | Hepatic Fibrosis/Hepatic Stellate Cell Activation | 0.0105 | 0.046 | +4, −2 |
| IL-4 Signaling | 0.00322 | 0.191 | +11, −2 | Hypoxia Signaling in the Cardiovascular System | 0.0157 | 0.056 | +0, −4 |
| Apoptosis Signaling | 0.00359 | 0.184 | +13, −3 | Notch Signaling | 0.018 | 0.073 | +1, −2 |
| Insositol Phosphate Metabolism | 0.0137 | 0.121 | +6, −5 | ||||
| Antigen presentation | 0.0169 | 0.154 | +6, −0 | ||||
| IGF-1 Signaling | 0.0204 | 0.163 | +12, −3 | ||||
| p53 Signaling | 0.022 | 0.149 | +12, −1 | ||||
|
CA3 | |||||||
| p53 Signaling | 0.00446 | 0.138 | +11, −1 | Protein Ubiquitination Pathway | 0.00108 | 0.119 | +16, −8 |
| Hypoxia Signaling in the Cardiovascular System | 0.0048 | 0.155 | +10, −1 | IGF-1 Signaling | 0.00116 | 0.163 | +12, −3 |
| Parkinson’s signaling | 0.0115 | 0.235 | +4, −0 | ERK/MAPK Signaling | 0.00402 | 0.122 | +16, −6 |
| PI3K/AKT signaling | 0.0168 | 0.113 | +10, −4 | Hypoxia Signaling in the Cardiovascular System | 0.00494 | 0.155 | +8, −3 |
| Biosynthesis of Steroids | 0.0309 | 0.039 | +2, −3 | Synaptic Long Term Potentiation | 0.0109 | 0.135 | +12, −3 |
| Protein Ubiquitinatioin | 0.0326 | 0.094 | +17, −2 | Cardiac β2-adrenergic Signaling | 0.012 | 0.115 | +13, −2 |
| Amyotrophic Lateral Sclerosis Signaling | 0.0389 | 0.107 | +8, − 3 | Insulin Receptor Signaling | 0.0138 | 0.12 | +14, −2 |
| Oxidative Phosphorylation | 0.0155 | 0.095 | +9, −6 | ||||
| Chemokine Signaling | 0.0166 | 0.147 | +9, −2 | ||||
| Glucocorticoid Receptor Signaling | 0.017 | 0.095 | +14, −2 | ||||
| PI3K/AKT Signaling | 0.0186 | 0.113 | +12, −2 | ||||
|
DG | |||||||
| PI3K/AKT signaling | 0.000293 | 0.113 | +10, −4 | Oxidative Phosphorylation | 0.00389 | 0.133 | +14, −7 |
| Oxidative Phosphorylation | 0.0019 | 0.082 | +12, −1 | IL-2 Signaling | 0.0108 | 0.208 | +8, −3 |
| Mitochondrial Dysfunction | 0.00251 | 0.073 | +10, −2 | PTEN Signaling | 0.0154 | 0.163 | +7, −8 |
| Ubiquinone Biosynthesis | 0.00416 | 0.067 | +7, −3 | Estrogen Receptor Signaling | 0.0203 | 0.144 | +8, −9 |
| Ceramide Signaling | 0.0115 | 0.101 | +4, −4 | EGF Signaling | 0.0214 | 0.191 | +6, −3 |
| P53 Signaling | 0.0165 | 0.092 | +7, −1 | Nucleotide Excision Repair Pathway | 0.0254 | 0.2 | +1, −6 |
| GM-CSF Signaling | 0.0339 | 0.177 | +6, −5 | ||||
|
Hippocampus | |||||||
| Antigen Presentation Pathway | 0.0000729 | 0.308 | +12,-0 | Protein Ubiquitination Pathway | 0.0018 | 0.218 | +18, −26 |
| Mitochondrial Dysfunction | 0.000192 | 0.2 | +26, −7 | GM-CSF Signaling | 0.008 | 0.29 | +11, −7 |
| NRF2-mediated Oxidative Stress Response | 0.00157 | 0.244 | +38, −6 | Nucleotide Excision Repair Pathway | 0.0205 | 0.286 | +2, −8 |
| Amyloid Processing | 0.002 | 0.346 | +15, −3 | Synaptic Long Term Potentiation | 0.021 | 0.243 | +19, −8 |
| Integrin Signaling | 0.00499 | 0.24 | +34, −12 | Antigen Presentation Pathway | 0.066 | 0.179 | +1, −6 |
| Huntington’s Disease Signaling | 0.0063 | 0.211 | +42, −7 | ||||
| Ubiquinone Biosynthesis | 0.00755 | 0.144 | +13, −2 | ||||
| Protein Ubiquitination Pathway | 0.00937 | 0.208 | +32, −10 | ||||
Pathways significantly altered (p) by caloric restriction or aging, the ratio of significantly altered pathway genes to total pathway genes members, and the number of genes in the corresponding pathway that were upregulated (+FC) or downregulated (−FC).