Table 3.

Regionally distinct treatment effects.

	Age Effect			Diet Effect			Pathways
Molecule	CA1	CA3	DG	CA1	CA3	DG
	IGF1-PI3K/AKT and P53-Apoptosis						IGF	AKT	P53	Apoptosis
ACIN1	1.62	1.53	1.54	NS	NS	NS				x
AKT1	1.61	1.53	1.46	NS	1.32	1.33	x	x	x
BAI1	1.39	1.61	NS	NS	1.33	1.4			x
BAX	1.71	1.81	1.93	NS	−1.47	−144			x	x
BIRC2	−1.36	NS	NS	NS	1.29	1.26				x
CAPNS1	1.42	NS	1.41	NS	NS	NS				x
CASP9	1.24	1.22	NS	NS	NS	NS	x			x
CTNNB1	NS	1.27	1.24	NS	−1.28	−1.28		x	x
GRB2	−3.17	−3.45	−2.09	NS	NS	NS	x	x
IGF1R	NS	NS	NS	1.73	1.68	1.39	x
IHPK2	1.87	1.61	NS	NS	1.35	1.5			x
JUN	1.77	1.7	NS	NS	NS	NS	x		x
NFKBIB	1.55	1.38	1.45	NS	NS	NS		x		x
P53	2.11	2.02	1.89	NS	NS	NS		x	x	x
PIK3CA	NS	NS	NS	NS	1.17	−1.55	x	x	x
PIK3R2	1.98	−3.13	−3.16	NS	2.75	3.88	x	x	x
PPKAR1B	NS	NS	NS	NS	1.14	1.23	x
PRKACB	−4.41	−3.35	−2.65	NS	2.66	2.89	x
SFN	1.65	1.75	NS	NS	NS	1.32	x	x	x
YWHAB	1.47	1.46	1.43	NS	NS	NS	x	x
	Oxidative Phosphorylation and Mitochondrial Dysfunction						OX-Phos	Myto-Dys
ATP5D	1.26	1.23	1.21	NS	NS	NS	x
ATP6V0A1	1.59	1.49	NS	NS	1.37	1.5	x
ATP6V0A2	1.37	NS	1.36	NS	NS	NS	x
ATP6V0B	NS	NS	NS	NS	6.38	1.24	x
ATP6V0D1	NS	NS	NS	NS	1.15	1.23	x
ATP6V1B2	NS	NS	NS	NS	1.17	1.22	x
ATP6V1G2	NS	NS	NS	NS	1.12	1.18	x
CASP9	1.24	1.22	NS	NS	NS	NS		x
COX5B	NS	1.16	1.14	NS	NS	NS	x	x
COX7B	NS	1.25	1.31	NS	−1.38	−1.36	x	x
GPX4	1.21	NS	1.23	NS	NS	NS		x
HCG25731	NS	NS	NS	NS	−1.09	1.12	x
IHPK2	1.87	1.61	NS	NS	1.35	1.5	x
MAP2K4	−1.24	NS	−1.27	NS	NS	NS		x
NDUFA7	−2.3	−1.78	NS	NS	1.9	2.87	x	x
NDUFS8	1.38	1.35	1.39	NS	NS	NS	x	x
NDUFV3	1.53	1.58	1.44	NS	−1.26	−1.59	x	x
UGCRQ	1.32	1.28	NS	NS	NS	NS	x
UQCRC1	NS	1.15	1.17	NS	NS	1.14	x	x
	Protein Ubiquitination
ANAPC2	1.36	1.38	1.44	NS	NS	NS
ANAPC5	NS	1.15	1.13	NS	NS	NS
BAG1	NS	1.38	1.27	NS	−1.34	−1.23
BIRC2	−1.36	NS	NS	NS	1.29	1.26
BTRC	1.67	1.72	1.75	NS	NS	NS
FZR1	1.54	1.42	1.53	NS	NS	1.33
PSMA3	NS	NS	NS	NS	−1.19	−1.26
PSMB5	NS	1.17	1.21	NS	NS	NS
PSMD14	NS	NS	NS	NS	1.64	−1.34
STUB1	NS	NS	1.17	NS	1.14	1.24
TAP2	5.51	4.83	NS	NS	NS	−3.11
THOP1	1.93	1.88	1.68	NS	NS	NS
UBA1	1.37	1.26	NS	NS	1.2	1.4
UBE2D2	NS	1.38	1.57	NS	2.2	1.4
UBE2J1	1.31	1.32	NS	NS	NS	NS
UBE2Q1	NS	1.17	NS	−1.37	−1.22	NS
UBE2S	1.67	1.94	1.95	NS	NS	NS
UBE2V1	NS	NS	NS	NS	1.1	1.18
UCHL3	NS	NS	NS	NS	−1.16	−1.15
USO1	−1.35	NS	−1.25	NS	NS	NS
USP11	NS	NS	NS	NS	1.17	1.29
USP22	NS	NS	NS	NS	1.73	1.53
USP5	1.27	1.21	NS	NS	1.28	1.33

Numbers represent significant fold change values; those that were not significant (NS) are indicated. Functional categories with multiple pathways indicate molecular inclusion (x).