Table 3.

Hypothetical annualized rates of percent brain volume change and corresponding effect sizes for subjects not older than 65 years based on estimations using generalized additive models.

Region	Control	sMCI	cMCI	AD	Effect size(1)
					sMCI	cMCI	AD
ERC(2)	-1.1 ± 2.8	-2.3 ± 3.1	-5.0 ± 3.6	-5.9 ± 3.9	0.4	1.3	1.4
HP(3)	-1.0 ± 1.9	-2.0 ± 2.1	-3.5 ± 2.2	-4.0 ± 2.3	0.5	1.2	1.3
LV(4)	+4.2 ± 3.6	+5.2 ± 4.3	+8.2 ± 4.7	+9.9 ± 5.3	0.2	1.1	1.3
FG(5)	-0.8 ± 2.0	-1.6 ± 2.2	-3.9 ± 2.3	-4.0 ± 2.9	0.3	0.9	1.3
PG(6)	-1.0 ± 2.3	-1.8 ± 2.7	-3.6 ± 2.8	-4.2 ± 2.8	0.3	1.1	1.2
ST(7)	-0.9 ± 1.8	-1.4 ± 2.0	-3.0 ± 2.5	-3.4 ± 2.9	0.2	0.9	1.0

Annualized rates listed as mean ± standard deviation;

⁽¹⁾Effect sizes computed as Cohen’s d, which is defined as the difference between the two means divided by the pooled standard deviation of the data;

⁽²⁾entorhinal cortex;

⁽³⁾hippocampus;

⁽⁴⁾lateral ventricles;

⁽⁵⁾fusiform gyrus;

⁽⁶⁾parahippocampal gyrus;

⁽⁷⁾superior temporal lobe gray matter;