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. Author manuscript; available in PMC: 2011 May 17.
Published in final edited form as: Cell Cycle. 2010 Jun 15;9(12):2317–2329. doi: 10.4161/cc.9.12.11902

Fig. 4. Strand-specific stimulation of FANCJ helicase activity past a thymine glycol base lesion by RPA.

Fig. 4

The model depicts the ability of the single-stranded DNA binding protein RPA to stimulate FANCJ helicase activity when the lesion resides in the strand opposite to the one that FANCJ translocates. RPA binds tightly to the partially unwound ssDNA containing the thymine glycol in the helicase non-translocating strand, enabling the helicase to proceed unwinding past the lesion. See text and ref. 90 for details. RPA, Replication Protein A heterotrimer; FANCJ helicase, triangle; TG oval, thymine glycol base damage.