Table 1.
Parameter (normal range) | Patient 1 | Patient 2 | Patient 3 |
---|---|---|---|
Serum IgG (751–1560 mg/dl) | <60 mg/dl | <100 mg/dl | <33 mg/dl |
Serum IgM (46–453 mg/dl) | 13 mg/dl | 17 mg/dl | 27mg/dl |
Serum IgA (46–304 mg/dl) | <4 mg/dl | 40 mg/dl | <7 mg/dl |
Serum IgE (0–100 IU/ml) | <1 IU/ml | N.D. | N.D. |
CD3+ (857–3112/μl) | 1305/μl | 934/μl | 1015/μl |
CD4+ (511–2245/μl) | 960/μl | 520/μl | 586/μl |
CD8+ (258–1394/μl) | 300/μl | 390/μl | 408/μl |
CD19+ (135–711/μl) | 30/μl | 142/μl | 10/μl |
IgD-/CD27+ B-cells1 | 4.3% | N.D. | N.D. |
Isotype-switched memory B-cells (normal range 8–40%)