Inter-helical contacts between F (orange), G (cyan) and I (magenta) helices are shown for P450cam bound to camphor (P450cam-C), AdaC1-C8-Dans (P450cam-I), AdaC1-C4-Dans (P450cam-O), and AdaC3-C8-Dans (P450cam-O). Salt bridge and hydrogen bonding interactions are shown in blue dash, while hydrophobic contacts are shown in as dotted spheres.