. 2010 Jun 11;86(6):860–871. doi: 10.1016/j.ajhg.2010.04.014

Table 2.

Power Comparison with Existing Pathway Approaches

Set	G¹	p²	Causal SNPs	α Level	Power
Set	G¹	p²	Causal SNPs	α Level	Wang	Plink	ALIGATOR	GRASS
E1	20	444	5³	0.05	0.48	0.68	0.41	0.87
				0.01	0.24	0.35	0.24	0.79
E2	20	444	5⁴	0.05	0.54	0.92	0.55	0.91
				0.01	0.18	0.50	0.16	0.80
F1	30	2286	same as in E1	0.05	0.29	0.44	0.18	0.87
				0.01	0.20	0.23	0.02	0.80
F2	30	2286	same as in E2	0.05	0.32	0.80	0.33	0.87
				0.01	0.17	0.61	0.13	0.73

Summary of power comparison of Wang et al.,⁷ Plink,¹⁸ ALIGATOR,⁹ and the proposed GRASS under various simulated scenarios.

Number of genes.

Total number of SNPs.

One causal SNP in each of the five smallest genes (range: 4–11 SNPs).

⁴

One causal SNP in each of the five largest genes (range: 28–91 SNPs).