Autosomal Population Structure and Mitochondrial Haplogroups in the MGH-AIS Cohort
(A) Autosomal population structure as represented by plotting autosomal PCs 1 and 2 and corresponding individual mitochondrial haplogroup assignment in the MGH-AIS cohort. Mitochondrial haplogroups clearly distinguish individuals of Asian and African ancestry from European American individuals, but they fail to correctly identify Mexican American individuals (identified as Asian haplogroup carriers).
(B) Autosomal population structure and mitochondrial haplogroup assignment in the European American MGH-AIS subjects. No intracontinental distribution of haplogroups is discernible within the European-ancestry cluster. Autosomal PCA was performed separately after the removal of individuals of non-European ancestry.