Table 2.

Dendrite and spine morphometry from layer III pyramidal neurons from htau and wt mice at 3, 6, and 12 months of age

Genotype	Morphology (μm)		Spine
			Density (spines/μm)		Type (%)
	Apical	Basal	Apical	Basal	Apical
					S	T	M
3 months
htau	1,338.6 ± 123.8	359.0 ± 26.4	1.40 ± 0.06	1.62 ± 0.11	28.42 ± 1.34	43.5 ± 3.59	27.81 ± 2.11
wt	1,635.4 ± 134.7	395.9 ± 19.8	1.42 ± 0.17	1.58 ± 0.09	23.96 ± 1.53	51.52 ± 1.47	24.81 ± 3.16
6 months
htau	1,330.0 ± 94.4	369.7 ± 22.6 *	1.70 ± 0.06	1.83 ± 0.08	25.44 ± 1.27	54.58 ± 2.52	20.0 ± 2.97
wt	1,374.8 ± 125.7	451.2 ± 12.9 *	1.69 ± 0.11	1.71 ± 0.1	25.46 ± 1.98	52.46 ± 1.13	21.96 ± 1.47
12 months
htau	1,429.5 ± 31.7	411.1 ± 28.8	1.96 ± 0.09	1.80 ± 0.07	31.92 ± 1.04	49.65 ± 1.86	18.45 ± 1.14
wt	1,382.9 ± 262.6	341.4 ± 39.9	2.13 ± 0.11	1.97 ± 0.16	28.69 ± 1.24	52.26 ± 1.74	19.02 ± 1.84

Genotype	Spine
	Type (%)			Volume (μm3)
	Basal			Apical			Basal
	S	T	M	S	T	M	S	T	M
3 months
htau	26.51 ± 1.25	45.56 ± 2.97	27.88 ± 1.77	0.11 ± 0.03	0.04 ± 0.002	0.22 ± 0.02	0.09 ± 0.01	0.03 ± 0.002	0.20 ± 0.01
wt	22.86 ± 0.53	51.86 ± 0.49	25.61 ± 0.32	0.07 ± 0.003	0.03 ± 0.001	0.18 ± 0.004	0.07 ± 0.001	0.03 ± 0.002	0.18 ± 0.001
6 months
htau	23.45 ± 1.27	56.12 ± 2.21	20.44 ± 1.62	0.07 ± 0.004	0.04 ± 0.002	0.21 ± 0.01	0.06 ± 0.004	0.04 ± 0.001	0.17 ± 0.01
wt	21.53 ± 1.27	57.29 ± 2.33	21.26 ± 1.97	0.08 ± 0.005	0.04 ± 0.003	0.21 ± 0.106	0.07 ± 0.002	0.04 ± 0.001	0.17 ± 0.005
12 months
htau	29.96 ± 1.52	49.4 ± 1.57 *	20.64 ± 0.85	0.08 ± 0.002	0.05 ± 0.003	0.25 ± 0.01	0.06 ± 0.001	0.04 ± 0.001	0.22 ± 0.01
wt	26.30 ± 1.25	54.11 ± 0.58 *	19.51 ± 1.38	0.07 ± 0.005	0.05 ± 0.003	0.25 ± 0.01	0.06 ± 0.001	0.04 ± 0.001	0.22 ± 0.01

S stubby spine, T thin spine, M mushroom spine

^*p<0.05